Venkata Satya Kumar Manem

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Bioinformatics researcher, Laval University - University Institute of Cardiology and Pulmonology of Quebec (IUCPQ) (2018-2020)

Postdoctoral research fellow (Bioinformatics and AI), Princess Margaret Cancer Center (2015-2018)

Postdoctoral research fellow (Department of Radiation Oncology), Harvard Medical School and Massachusetts General Hospital (2014-2015)

PhD (Applied Mathematics - Mathematical medicine), University of Waterloo, Canada (2014)

MSc (Mathematics), Memorial University of Newfoundland, Canada (2009)

MSc (Mathematics with spec. in Computer Science), Sri Sathya Sai Institute of Higher Learning, India (2005)

Cancer, Génomique, biomarqueurs de réponse à la radiothérapie et à l'immunothérapie, Bioinformatique, Intelligence artificielle.

(Cancer, Genomics, Biomarker response to radiotherapy and immunotherapy, Bioinformatics, Artificial Intelligence)

Google Scholar: https://scholar.google.com/citations?user=NL5x8moAAAAJ

1. Sorin M, Karimi E, Rezanejad M, Yu M, Desharnais L, McDowell S, Dore S, Arabzadeh A, Breton V, Fiset B, Wei Y, Rayes R, Orain M, Coulombe F, Manem V , Gagne A, Quail DF , Joubert P, Spicer JD, Walsh LA (2022) Single-cell spatial landscape of immunotherapy response reveals opportunities to boost anti-tumor immunity through CXCL13, Cancer Discovery (under review).
2. Dow MA, Secco B, Mouchiroud M, Rochette M, Gilio GR, Massicard M, Gélinas Y, Lamothe J, Festuccia WT, Morissette MC, Manem VSK , Laplante M (2022) VSTM2A loss impairs healthy adipose tissue development and disrupts glucose and lipid homeostasis, Molecular Metabolism (under review).
3. Manem VSK (2021) Discovery and validation of genomics predictors of radiation sensitivity using preclinical data. BMC Cancer 21 (1), 1-9
4. Villot R, Poirier A, Bakan I, Fernandez E, Devillers R, Gama-Braga L, Gagné A, Boulay K, Caron D, Bérubé J, Coulombe Y, Orain M, Gélinas Y, Gobeil S, Bossé Y, Masson Y, Elowe S, Bilodeau S, Manem VSK , Joubert P, Mallette F, Laplante M (2021). ZNF768 links oncogenic RAS to cellular senescence. NatureCommunications .
5. Manem VSK , Sazonova O, Orain M, Bossé Y, Joubert P. (2021) Unraveling actionable biology using transcriptomic data to integrate mitotic index and Ki-67 in the management of lung neuroendocrine tumors. Oncotarget 12 (3), 209
6. Amgad M, Stovgaard ES, Balslev E, International Immuno-Oncology Biomarker Working Group (2020) Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group. NPJ breast cancer 6 (1), 1-13
7. Laflamme P, Mansoori BK, Sazanova O, Orain M, Couture C, Simard S, Trahan S, Manem VSK, Joubert P. (2020) PHH3 Immunostaining for Carcinoid tumor of the lung: impact on clinical appraisal, interobserver correlation and diagnostic processing efficiency. Histopathology.
8. Sazonova O, Manem VSK, Béland C, Hamel MA, Lacasse Y, et al. (2020) Development and Validation of Diffuse Idiopathic Pulmonary Neuroendocrine Hyperplasia (DIPNECH) Diagnostic Criteria. JTO Clinical and Research Reports 100078.
9. Sazonova O, Manem VSK, Orain M, Bossé Y, Joubert P. (2020) Transcriptomic data helps refining classification of pulmonary carcinoid tumors with increased mitotic counts. Modern Pathology 1-10
10. Kachuri L, Johansson M, Rashkin SR, Graff RE, Bossé Y, Manem VSK, et al. (2020) Genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility. Nature Communications 11(1)
11. Bossé Y, Li Z, Xia J, Manem VSK, et al. (2020) Transcriptome-wide association study reveals candidate causal genes for lung cancer. International Journal of Cancer
12. Manem VSK, Dhawan A. (2019) RadiationGeneSigDB: A comprehensive database of oxic and hypoxic radiation response gene expression signatures and their utility in identification of hypoxia regulated MicroRNA. The British Journal of Radiology 92: 20190198
13. Manem VSK, Lambie M, Smirnov P, Kofia V, et al. (2019) Modeling cellular response in large-scale radiogenomic databases to advance precision radiotherapy. Cancer Research 79(24)
14. Tonekaboni SA, Manem VSK, El-Hachem N, Haibe-Kains B. (2019) Similarity identification in gene expression patterns as a new approach in phenotype classification. Bioinformatics 35(22)
15. Gendoo DMA, Zon M, Sandhu V, Manem VSK, et al. (2019) MetaGxData: Clinically Annotated Breast, Ovarian and Pancreatic Cancer Datasets and their Use in Generating a Multi-Cancer Gene Signature. Scientific Reports
16. Gruosso T, Gigoux M, Manem VSK, et al. (2019) Distinct immune microenvironments stratify Triple Negative Breast Cancer and predict outcome. Journal of Clinical Investigation 129(4)
17. Clouthier DL, Lien S, Yang SYC, Gray D, Nguyen LT, Manem VSK, et al. (2019) A technical feasibility report on the Investigator-initiated Phase 2 Study of Pembrolizumab Immunological Response Evaluation (INSPIRE) study. Journal for Immunotherapy of Cancer 7(1)
18. Manem VSK, Adam AG, Bertos N, Park M, Haibe-Kains B. (2018) CrosstalkNet: A visualization tool for differential co-expression networks and communities. Cancer Research 78 (8)
19. Manem VSK, Salgado R, Aftimos P, Sotiriou C, Haibe-Kains B. (2017) Network Science in Clinical Trials: a patient-centered approach. Seminars in Cancer Biology.
20. Manem VSK, Grassberger C, Paganetti H. (2017) Predicting organ specific interactions between radiation and chemotherapy in secondary cancer survivors. Cancers 9 (9), 119.
21. Manem VSK, Dhawan A. (2017) Modelling Recurrence and Secondary Cancer Risks induced by Proton therapy. Mathematical Medicine and Biology: A Journal of the IMA.
22. Manem VSK, Kohandel M, et al. (2017) Predictive modeling of treatment induced secondary thyroid malignancies in childhood cancer patients. Convergent Science of Physical Oncology, 3(3)
23. Yao F, Tonekaboni SA, Safikhani Z, Smirnov P, El-Hachem N, Freeman M, Manem VSK, Haibe-Kains B. (2017) Tissue specificity of in-vitro drug sensitivity. Journal of the American Medical Informatics Association 25(2)
24. Madani SA, Laleh SG, Manem VSK, Haibe-Kains B. (2016) Predictive approaches for drug combination discovery in cancer. Briefings in Bioinformatics 19(2)
25. Manem VSK, Kaveh K, Kohandel M, Sivaloganathan S. (2015) Modelling Invasion Dynamics with Spatial Random Fitness due to Microenvironment. PLoS One 10(10)
26. Kaveh K, Manem VSK, Kohandel M, Sivaloganathan S. (2015) Modeling Age Dependent Radiation Induced Second Cancer Risks and Estimation of Mutation Rate- An Evolutionary Approach. Radiation and Environmental Biophysics. 54(1)
27. Manem VSK, Kohandel M, Hodgson DC, et al. (2015) The effect of Radiation Quality on the risks of Second Malignancies. International Journal of Radiation Biology 91(3)
28. Manem VSK, Dhawan A, et al. (2014) Efficacy of dose escalation on TCP, recurrence and second cancer risks: A mathematical study. The British Journal of Radiology 87(1043)
29. Manem VSK , Kohandel M, Komarova NL, Sivaloganathan S. (2014) Spatial Invasion Dynamics on Random and Unstructured Meshes: Implications for Heterogeneous Tumor Populations. Journal of Theoretical Biology 129(4)

1. FRQS Research Fellows - Junior 1 Scholar Award (2020-2024)
2. The immunoTherapy NeTwork Annual Meeting Travel Award (2017) of $1000 CAD, Canada
3. Office of Research Trainees Travel Award (2017) of $500 CAD, PMH, Canada

Research Associate:

1. Fabien Lamaze, University Institute of Cardiology and Pulmonology of Quebec (IUCPQ) (2022-)

Students (graduate students, on-going):

1. Seyyedali Hosseini, PhD candidate, Laval University - University Institute of Cardiology and Pulmonology of Quebec (IUCPQ) (2022-); co-director

2. Fahime Sokhangou, PhD candidate at Laval University - University Institute of Cardiology and Pulmonology of Quebec (IUCPQ) (2022-); co-director

3. Alona Kolnoguz, PhD candidate at Laval University - University Institute of Cardiology and Pulmonology of Quebec (IUCPQ) (2022-); co-director

4. Clémence Boullier, PhD candidate at Laval University - University Institute of Cardiology and Pulmonology of Quebec (IUCPQ) (2022-); co-director

5. Cheik Sall, MSc candidate at UQTR (2022-); director

6. Mbene Diop, MSc candidate at UQTR (2022-); co-director

Completed:

1. Alona Kolnoguz, intern at Laval University (May - August 2021); co-director